pf 05089771 Search Results


pf 05089771  (Tocris)
94
Tocris pf 05089771
Pf 05089771, supplied by Tocris, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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pf 05089771 - by Bioz Stars, 2026-02
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pf 05089771  (Alomone Labs)
93
Alomone Labs pf 05089771
Na v 1.7 inhibitor <t>PF-05089771</t> blunted the effect of Narirutin on sodium currents. ( a ) Representative traces of Na + currents in DRG sensory neurons after blocking Na v 1.7 with 0.1% DMSO + 100 nM PF-05089771 or 20 µM Narirutin + 100 nM PF-05089771 treatment. Currents were evoked by 200 ms pulses between −70 and +60 mV. Summary of ( b ) the normalized (pA/pF) sodium current density versus voltage relationship and ( c ) peak Na + current density (Na v 1.7 blocked) at −10 mV from DRG neurons treated as indicated. Boltzmann fits for normalized conductance, G/Gmax voltage relationships for voltage-dependent ( d ) activation, and ( e ) inactivation sensory neurons. The half-maximal activation (V 1/2 ) and slope values ( k ) for activation and inactivation are summarized in . Data are expressed as means ± SEM. ( p > 0.05, Mann–Whitney test, n > 9 cells per condition).
Pf 05089771, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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pf 05089771 - by Bioz Stars, 2026-02
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pf 05089771  (MedChemExpress)
91
MedChemExpress pf 05089771
Na v 1.7 inhibitor <t>PF-05089771</t> blunted the effect of Narirutin on sodium currents. ( a ) Representative traces of Na + currents in DRG sensory neurons after blocking Na v 1.7 with 0.1% DMSO + 100 nM PF-05089771 or 20 µM Narirutin + 100 nM PF-05089771 treatment. Currents were evoked by 200 ms pulses between −70 and +60 mV. Summary of ( b ) the normalized (pA/pF) sodium current density versus voltage relationship and ( c ) peak Na + current density (Na v 1.7 blocked) at −10 mV from DRG neurons treated as indicated. Boltzmann fits for normalized conductance, G/Gmax voltage relationships for voltage-dependent ( d ) activation, and ( e ) inactivation sensory neurons. The half-maximal activation (V 1/2 ) and slope values ( k ) for activation and inactivation are summarized in . Data are expressed as means ± SEM. ( p > 0.05, Mann–Whitney test, n > 9 cells per condition).
Pf 05089771, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 91/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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pf 05089771 - by Bioz Stars, 2026-02
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pf05089771  (Tocris)
93
Tocris pf05089771
Na v 1.7 inhibitor <t>PF-05089771</t> blunted the effect of Narirutin on sodium currents. ( a ) Representative traces of Na + currents in DRG sensory neurons after blocking Na v 1.7 with 0.1% DMSO + 100 nM PF-05089771 or 20 µM Narirutin + 100 nM PF-05089771 treatment. Currents were evoked by 200 ms pulses between −70 and +60 mV. Summary of ( b ) the normalized (pA/pF) sodium current density versus voltage relationship and ( c ) peak Na + current density (Na v 1.7 blocked) at −10 mV from DRG neurons treated as indicated. Boltzmann fits for normalized conductance, G/Gmax voltage relationships for voltage-dependent ( d ) activation, and ( e ) inactivation sensory neurons. The half-maximal activation (V 1/2 ) and slope values ( k ) for activation and inactivation are summarized in . Data are expressed as means ± SEM. ( p > 0.05, Mann–Whitney test, n > 9 cells per condition).
Pf05089771, supplied by Tocris, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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pf05089771 - by Bioz Stars, 2026-02
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lead sulphonamide pf-05089771  (Pfizer Inc)
90
Pfizer Inc lead sulphonamide pf-05089771
Na v 1.7 inhibitor <t>PF-05089771</t> blunted the effect of Narirutin on sodium currents. ( a ) Representative traces of Na + currents in DRG sensory neurons after blocking Na v 1.7 with 0.1% DMSO + 100 nM PF-05089771 or 20 µM Narirutin + 100 nM PF-05089771 treatment. Currents were evoked by 200 ms pulses between −70 and +60 mV. Summary of ( b ) the normalized (pA/pF) sodium current density versus voltage relationship and ( c ) peak Na + current density (Na v 1.7 blocked) at −10 mV from DRG neurons treated as indicated. Boltzmann fits for normalized conductance, G/Gmax voltage relationships for voltage-dependent ( d ) activation, and ( e ) inactivation sensory neurons. The half-maximal activation (V 1/2 ) and slope values ( k ) for activation and inactivation are summarized in . Data are expressed as means ± SEM. ( p > 0.05, Mann–Whitney test, n > 9 cells per condition).
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pf-05089771  (Icagen Inc)
90
Icagen Inc pf-05089771
Na v 1.7 inhibitor <t>PF-05089771</t> blunted the effect of Narirutin on sodium currents. ( a ) Representative traces of Na + currents in DRG sensory neurons after blocking Na v 1.7 with 0.1% DMSO + 100 nM PF-05089771 or 20 µM Narirutin + 100 nM PF-05089771 treatment. Currents were evoked by 200 ms pulses between −70 and +60 mV. Summary of ( b ) the normalized (pA/pF) sodium current density versus voltage relationship and ( c ) peak Na + current density (Na v 1.7 blocked) at −10 mV from DRG neurons treated as indicated. Boltzmann fits for normalized conductance, G/Gmax voltage relationships for voltage-dependent ( d ) activation, and ( e ) inactivation sensory neurons. The half-maximal activation (V 1/2 ) and slope values ( k ) for activation and inactivation are summarized in . Data are expressed as means ± SEM. ( p > 0.05, Mann–Whitney test, n > 9 cells per condition).
Pf 05089771, supplied by Icagen Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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pf-05089771 - by Bioz Stars, 2026-02
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pf-05089771  (Pharmatech)
90
Pharmatech pf-05089771
Na v 1.7 inhibitor <t>PF-05089771</t> blunted the effect of Narirutin on sodium currents. ( a ) Representative traces of Na + currents in DRG sensory neurons after blocking Na v 1.7 with 0.1% DMSO + 100 nM PF-05089771 or 20 µM Narirutin + 100 nM PF-05089771 treatment. Currents were evoked by 200 ms pulses between −70 and +60 mV. Summary of ( b ) the normalized (pA/pF) sodium current density versus voltage relationship and ( c ) peak Na + current density (Na v 1.7 blocked) at −10 mV from DRG neurons treated as indicated. Boltzmann fits for normalized conductance, G/Gmax voltage relationships for voltage-dependent ( d ) activation, and ( e ) inactivation sensory neurons. The half-maximal activation (V 1/2 ) and slope values ( k ) for activation and inactivation are summarized in . Data are expressed as means ± SEM. ( p > 0.05, Mann–Whitney test, n > 9 cells per condition).
Pf 05089771, supplied by Pharmatech, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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pf-05089771 - by Bioz Stars, 2026-02
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pf-05089771 [2,2-diphenyl-n-(4-(n-thiazol-2-ylsulfamoyl)phenyl)acetamide]  (Neusentis)
90
Neusentis pf-05089771 [2,2-diphenyl-n-(4-(n-thiazol-2-ylsulfamoyl)phenyl)acetamide]
Na v 1.7 inhibitor <t>PF-05089771</t> blunted the effect of Narirutin on sodium currents. ( a ) Representative traces of Na + currents in DRG sensory neurons after blocking Na v 1.7 with 0.1% DMSO + 100 nM PF-05089771 or 20 µM Narirutin + 100 nM PF-05089771 treatment. Currents were evoked by 200 ms pulses between −70 and +60 mV. Summary of ( b ) the normalized (pA/pF) sodium current density versus voltage relationship and ( c ) peak Na + current density (Na v 1.7 blocked) at −10 mV from DRG neurons treated as indicated. Boltzmann fits for normalized conductance, G/Gmax voltage relationships for voltage-dependent ( d ) activation, and ( e ) inactivation sensory neurons. The half-maximal activation (V 1/2 ) and slope values ( k ) for activation and inactivation are summarized in . Data are expressed as means ± SEM. ( p > 0.05, Mann–Whitney test, n > 9 cells per condition).
Pf 05089771 [2,2 Diphenyl N (4 (N Thiazol 2 Ylsulfamoyl)Phenyl)Acetamide], supplied by Neusentis, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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compound pf-05089771  (Pfizer Inc)
90
Pfizer Inc compound pf-05089771
Na v 1.7 inhibitor <t>PF-05089771</t> blunted the effect of Narirutin on sodium currents. ( a ) Representative traces of Na + currents in DRG sensory neurons after blocking Na v 1.7 with 0.1% DMSO + 100 nM PF-05089771 or 20 µM Narirutin + 100 nM PF-05089771 treatment. Currents were evoked by 200 ms pulses between −70 and +60 mV. Summary of ( b ) the normalized (pA/pF) sodium current density versus voltage relationship and ( c ) peak Na + current density (Na v 1.7 blocked) at −10 mV from DRG neurons treated as indicated. Boltzmann fits for normalized conductance, G/Gmax voltage relationships for voltage-dependent ( d ) activation, and ( e ) inactivation sensory neurons. The half-maximal activation (V 1/2 ) and slope values ( k ) for activation and inactivation are summarized in . Data are expressed as means ± SEM. ( p > 0.05, Mann–Whitney test, n > 9 cells per condition).
Compound Pf 05089771, supplied by Pfizer Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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pf-05089771  (Amgen)
90
Amgen pf-05089771
Na v 1.7 inhibitor <t>PF-05089771</t> blunted the effect of Narirutin on sodium currents. ( a ) Representative traces of Na + currents in DRG sensory neurons after blocking Na v 1.7 with 0.1% DMSO + 100 nM PF-05089771 or 20 µM Narirutin + 100 nM PF-05089771 treatment. Currents were evoked by 200 ms pulses between −70 and +60 mV. Summary of ( b ) the normalized (pA/pF) sodium current density versus voltage relationship and ( c ) peak Na + current density (Na v 1.7 blocked) at −10 mV from DRG neurons treated as indicated. Boltzmann fits for normalized conductance, G/Gmax voltage relationships for voltage-dependent ( d ) activation, and ( e ) inactivation sensory neurons. The half-maximal activation (V 1/2 ) and slope values ( k ) for activation and inactivation are summarized in . Data are expressed as means ± SEM. ( p > 0.05, Mann–Whitney test, n > 9 cells per condition).
Pf 05089771, supplied by Amgen, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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pf-05089771  (AstraZeneca ltd)
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Na v 1.7 inhibitor <t>PF-05089771</t> blunted the effect of Narirutin on sodium currents. ( a ) Representative traces of Na + currents in DRG sensory neurons after blocking Na v 1.7 with 0.1% DMSO + 100 nM PF-05089771 or 20 µM Narirutin + 100 nM PF-05089771 treatment. Currents were evoked by 200 ms pulses between −70 and +60 mV. Summary of ( b ) the normalized (pA/pF) sodium current density versus voltage relationship and ( c ) peak Na + current density (Na v 1.7 blocked) at −10 mV from DRG neurons treated as indicated. Boltzmann fits for normalized conductance, G/Gmax voltage relationships for voltage-dependent ( d ) activation, and ( e ) inactivation sensory neurons. The half-maximal activation (V 1/2 ) and slope values ( k ) for activation and inactivation are summarized in . Data are expressed as means ± SEM. ( p > 0.05, Mann–Whitney test, n > 9 cells per condition).
Pf 05089771, supplied by AstraZeneca ltd, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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pf-05089771  (Neusentis)
90
Neusentis pf-05089771
Na v 1.7 inhibitor <t>PF-05089771</t> blunted the effect of Narirutin on sodium currents. ( a ) Representative traces of Na + currents in DRG sensory neurons after blocking Na v 1.7 with 0.1% DMSO + 100 nM PF-05089771 or 20 µM Narirutin + 100 nM PF-05089771 treatment. Currents were evoked by 200 ms pulses between −70 and +60 mV. Summary of ( b ) the normalized (pA/pF) sodium current density versus voltage relationship and ( c ) peak Na + current density (Na v 1.7 blocked) at −10 mV from DRG neurons treated as indicated. Boltzmann fits for normalized conductance, G/Gmax voltage relationships for voltage-dependent ( d ) activation, and ( e ) inactivation sensory neurons. The half-maximal activation (V 1/2 ) and slope values ( k ) for activation and inactivation are summarized in . Data are expressed as means ± SEM. ( p > 0.05, Mann–Whitney test, n > 9 cells per condition).
Pf 05089771, supplied by Neusentis, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Image Search Results


Na v 1.7 inhibitor PF-05089771 blunted the effect of Narirutin on sodium currents. ( a ) Representative traces of Na + currents in DRG sensory neurons after blocking Na v 1.7 with 0.1% DMSO + 100 nM PF-05089771 or 20 µM Narirutin + 100 nM PF-05089771 treatment. Currents were evoked by 200 ms pulses between −70 and +60 mV. Summary of ( b ) the normalized (pA/pF) sodium current density versus voltage relationship and ( c ) peak Na + current density (Na v 1.7 blocked) at −10 mV from DRG neurons treated as indicated. Boltzmann fits for normalized conductance, G/Gmax voltage relationships for voltage-dependent ( d ) activation, and ( e ) inactivation sensory neurons. The half-maximal activation (V 1/2 ) and slope values ( k ) for activation and inactivation are summarized in . Data are expressed as means ± SEM. ( p > 0.05, Mann–Whitney test, n > 9 cells per condition).

Journal: International Journal of Molecular Sciences

Article Title: Reversal of Peripheral Neuropathic Pain by the Small-Molecule Natural Product Narirutin via Block of Na v 1.7 Voltage-Gated Sodium Channel

doi: 10.3390/ijms232314842

Figure Lengend Snippet: Na v 1.7 inhibitor PF-05089771 blunted the effect of Narirutin on sodium currents. ( a ) Representative traces of Na + currents in DRG sensory neurons after blocking Na v 1.7 with 0.1% DMSO + 100 nM PF-05089771 or 20 µM Narirutin + 100 nM PF-05089771 treatment. Currents were evoked by 200 ms pulses between −70 and +60 mV. Summary of ( b ) the normalized (pA/pF) sodium current density versus voltage relationship and ( c ) peak Na + current density (Na v 1.7 blocked) at −10 mV from DRG neurons treated as indicated. Boltzmann fits for normalized conductance, G/Gmax voltage relationships for voltage-dependent ( d ) activation, and ( e ) inactivation sensory neurons. The half-maximal activation (V 1/2 ) and slope values ( k ) for activation and inactivation are summarized in . Data are expressed as means ± SEM. ( p > 0.05, Mann–Whitney test, n > 9 cells per condition).

Article Snippet: Neutral protease (Worthington, LS02104), IA collagenase (Worthington, LS004194), Poly-D-lysine hydrobromide (Sigma, P7886), DMEM (Gibco, 2318815), fetal bovine serum (Gibco, 2176404), penicillin/streptomycin (Gibco, 2321127), JetPrime (Polyplus, 101000046), TTX (Alomone, T-550), A803467 (Alomone, A-105), PF-05089771 (Alomone, P-315).

Techniques: Blocking Assay, Activation Assay, MANN-WHITNEY